Modeling cardiac mechano-electrical feedback using reaction-diffusion-mechanics systems
نویسندگان
چکیده
In many practically important cases, wave propagation described by the reaction-diffusion equation initiates deformation of the medium. Mathematically, such processes are described by coupled reactiondiffusion-mechanics (RDM) systems. RDM systemswere recently used to study the effects of deformation on wave propagation in cardiac tissue, so called mechano-electrical feedback (MEF). In this article, we review the results of some of these studies, in particular those relating to the effects of deformation on pacemaker activity and spiral wave dynamics in the heart. We also provide brief descriptions of the numerical methods used, and the underlying cardiac physiology. © 2008 Elsevier B.V. All rights reserved.
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